We describe a case of severe anticholinergic intoxication following th
e topical instillation of tropicamide-containing eyedrops. Tropicamide
is a short-acting atropine-like derivative and has been regarded as a
n effective and safe mydriatic. Half an hour after routine fundoscopy,
a 62-year-old man experienced two generalized seizures with respirato
ry arrest and required intubation and mechanical ventilation. The pati
ent was treated with physostigmine and made a full recovery.