THERAPEUTIC VACCINATION AGAINST CHRONIC VIRAL-INFECTION - THE IMPORTANCE OF COOPERATION BETWEEN CD4(-CELLS() AND CD8(+) T)

Authors
ZAJAC AJ MURALIKRISHNA K BLATTMAN JN AHMED R
Citation
Aj. Zajac et al., THERAPEUTIC VACCINATION AGAINST CHRONIC VIRAL-INFECTION - THE IMPORTANCE OF COOPERATION BETWEEN CD4(-CELLS() AND CD8(+) T), Current opinion in immunology, 10(4), 1998, pp. 444-449
Citations number
53
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
10
Issue
4
Year of publication
1998
Pages
444 - 449
Database
ISI
SICI code
0952-7915(1998)10:4<444:TVACV->2.0.ZU;2-1
Abstract
The goal of therapeutic vaccination is to elicit an antiviral immune r esponse within persistently infected individuals and consequently erad icate the infection. CD8(+) T cells are potent mediators of viral clea rance; however, during chronic infections CD4(+) T cell help is requir ed to sustain antiviral CD8(+) T cell activity. Therapeutic vaccinatio n should be targeted towards enhancing both CD4(+) and CD8(+) T cell v irus-specific responses.