CYTOTOXIC T-CELL RESPONSES TO INTRACELLULAR PATHOGENS

Host defense against intracellular pathogens is thought to require cyt otoxic T cells, Recent studies have investigated the impact of host ce ll lysis and cytokine production by cytotoxic T lymphocytes on the fat e of intracellular pathogens. The identification of two mechanisms of lysis induced by cytotoxic T lymphocytes - the granule exocytosis path way and the Fas-FasL interaction - have provided new insight into the role of cytotoxic T lymphocyters in immunity to infection.