CASE-REPORT - ADVANCED PATERNAL AGE AND DE-NOVO COMPLEX CHROMOSOMAL REARRANGEMENT IN OFFSPRING

Authors
BENZACKEN B SIFFROI JP STRAUB B LEBOURHIS C SAUVION S GAUDELUS J DADOUNE JP WOLF JP
Citation
B. Benzacken et al., CASE-REPORT - ADVANCED PATERNAL AGE AND DE-NOVO COMPLEX CHROMOSOMAL REARRANGEMENT IN OFFSPRING, Human reproduction (Oxford. Print), 13(7), 1998, pp. 1801-1803
Citations number
23
Categorie Soggetti
Reproductive Biology","Obsetric & Gynecology
Journal title
Human reproduction (Oxford. Print) → ACNP
ISSN journal
02681161
Volume
13
Issue
7
Year of publication
1998
Pages
1801 - 1803
Database
ISI
SICI code
0268-1161(1998)13:7<1801:C-APAA>2.0.ZU;2-K
Abstract
We report one case of a de-novo complex chromosomal rearrangement (CCR ), t(1;5;13)ins(14; 13), in an abnormal 19-month-old boy. Clinical fea tures associated were a mild facial dysmorphy and a psychomotor retard ation. Parental ages were, respectively, 29 years for the mother and 6 0 years for the father. We point out the usefulness of fluorescence in -situ hybridization in elucidating CCRs, and discuss the possible corr elation between the existence of a chromosomal aberration and advanced paternal age.