For 6 days, 10 male and 10 female social drinkers performed a rotary p
ursuit task six times across each day under both placebo and alcohol-i
ntoxicated conditions. Following a training period, 0.35g/kg of alcoho
l or placebo beverages were administered 45 min before the second, thi
rd, and fourth sessions each day. In general, alcohol impaired the rot
ary pursuit performance of women more than that of men despite similar
peak BAC levels. Results suggest no evidence of acute tolerance, evid
enced by similar performance on the ascending and descending limbs of
the BAC curve. However, results suggest that across the two alcohol ad
ministration days, men tended to develop some tolerance to the deleter
ious effect of alcohol on performance, whereas women became more sensi
tive to the effect of alcohol on performance. These results indicate t
hat there may be gender differences in the effects of repeated alcohol
administration on motor performance.