CONVENIENT AND SIMPLIFIED APPROACHES TO N-MONOPROTECTED TRIAMINOPROPANE DERIVATIVES - KEY INTERMEDIATES FOR BIFUNCTIONAL CHELATING AGENT SYNTHESIS

High yields of selectively N-protected-1,2,3-triaminopropanes (1,3 or 1,2 functionalized diamines) were obtained in 6 or 4 steps from diamin o alcohols or aminodiols, respectively. These two multi-step procedure s involve protection of (he amino group, substitution of the hydroxy g roup by an azido group and selective reduction. The conditions for the first procedure allow the preparation of various N-2-monoprotected-1, 2,3-triaminopropanes 6a, 6b, but the second one is more convenient for obtaining N-1-Boc-1,2,3-triaminopropane 6'. These two simplified proc edures, which provide functionalized 1,2 or 1,3 diamines easily and wi th good overall yields, could be useful for the synthesis of bifunctio nal chelating agents.