Felty's syndrome is a rare disorder characterized as a systemic manife
station of severe rheumatoid arthritis associated with granulocytopeni
a and splenomegaly. We report a retrospective analysis of a series of
seven patients treated successfully with low-dose methotrexate, leadin
g to sustained clinical improvement (number of swollen joints) and nor
malization of the granulocyte count for an observation period of 1 yr.
Our cohort is the largest ever published with methotrexate treatment
of this rare condition. Our results confirm earlier single case report
s suggesting methotrexate to be the first-choice treatment nowadays in
Felty's syndrome.