SOLID SUPPORT SYNTHESIS OF 14-MEMBERED MACROCYCLES CONTAINING THE THIOETHER BRIDGE VIA SNAR METHODOLOGY

Authors
KISELYOV AS EISENBERG S LUO Y
Citation
As. Kiselyov et al., SOLID SUPPORT SYNTHESIS OF 14-MEMBERED MACROCYCLES CONTAINING THE THIOETHER BRIDGE VIA SNAR METHODOLOGY, Tetrahedron, 54(36), 1998, pp. 10635-10640
Citations number
41
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
36
Year of publication
1998
Pages
10635 - 10640
Database
ISI
SICI code
0040-4020(1998)54:36<10635:SSSO1M>2.0.ZU;2-1
Abstract
An efficient assembly of 14-membered macrocycles utilizing the SNAr of fluorine in 3-fluoro-4-nitrobenzoic acid with the SH of cysteine on s olid support is reported. The flexibility of this synthesis, as well a s the excellent;purity (>90%) of the final products, are the distincti ve characteristics of the resulting library. (C) 1998 Elsevier Science Ltd. All rights reserved.