THIAISATOIC ANHYDRIDES - EFFICIENT SYNTHESIS UNDER MICROWAVE-HEATING CONDITIONS AND STUDY OF THEIR REACTIVITY

Authors
FABIS F JOLIVETFOUCHET S ROBBA M LANDELLE H RAULT S
Citation
F. Fabis et al., THIAISATOIC ANHYDRIDES - EFFICIENT SYNTHESIS UNDER MICROWAVE-HEATING CONDITIONS AND STUDY OF THEIR REACTIVITY, Tetrahedron, 54(36), 1998, pp. 10789-10800
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
36
Year of publication
1998
Pages
10789 - 10800
Database
ISI
SICI code
0040-4020(1998)54:36<10789:TA-ESU>2.0.ZU;2-5
Abstract
2-thiaisatoic anhydride 1 and 3-thiaisatoic anhydride 2 were synthesiz ed in large scale under microwave heating conditions with 85% and 67% yields respectively. The reactivity of these two compounds was studied towards various nucleophiles and appeared to be generally different f rom that of isatoic anhydride : many new thiophene-2 and 3-carboxylic acids were isolated with good yields as potential new pharmacological scaffolds. (C) 1998 Elsevier Science Ltd. AU rights reserved.