RU(II)-CATALYZED RING CLOSING METATHESIS IN STEREOSELECTIVE SYNTHESESOF CONSTRAINED HOMOSERINE ANALOGS

Authors
HAMMER K ROMMING C UNDHEIM K
Citation
K. Hammer et al., RU(II)-CATALYZED RING CLOSING METATHESIS IN STEREOSELECTIVE SYNTHESESOF CONSTRAINED HOMOSERINE ANALOGS, Tetrahedron, 54(36), 1998, pp. 10837-10850
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
36
Year of publication
1998
Pages
10837 - 10850
Database
ISI
SICI code
0040-4020(1998)54:36<10837:RRCMIS>2.0.ZU;2-P
Abstract
Stereoselective syntheses of cyclic alpha-amipo-gamma-hydroxycyclohexe ne- and cycloheptene-alpha-carboxylic acids are described. RCM cycliza tion reactions were effected by Ru(II)-catalysis on sterically homogen ous hydroxylated dienes. The diene substrates were available by stepwi se, stereoselective alkylations of (R)-2,5-dihydro-3,6-dimethoxy-2-iso propylpyrazine with bromoalkenes, ethylene oxide and subsequent transf ormations. (C) 1998 Elsevier Science Ltd. All rights reserved.