HIGHLY EFFICIENT SYNTHESIS OF ALPHA,BETA-ACETYLENIC ALDEHYDES FROM TERMINAL ALKYNES USING DMF AS THE FORMYLATING REAGENT

Authors
JOURNET M CAI DW DIMICHELE LM LARSEN RD
Citation
M. Journet et al., HIGHLY EFFICIENT SYNTHESIS OF ALPHA,BETA-ACETYLENIC ALDEHYDES FROM TERMINAL ALKYNES USING DMF AS THE FORMYLATING REAGENT, Tetrahedron letters, 39(36), 1998, pp. 6427-6428
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
36
Year of publication
1998
Pages
6427 - 6428
Database
ISI
SICI code
0040-4039(1998)39:36<6427:HESOAA>2.0.ZU;2-S
Abstract
The formylation of lithium acetylides with DMF led to alpha,beta-acety lenic aldehydes in excellent yields (>94%). A reverse quench into a ph osphate buffer (10% aqueous KH2PO4 ,4 equiv) proved ro he the key for this high-yielding reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.