A general approach to the solution phase parallel synthesis of perhydr
ooxazin-4-ones, which allows the preparation of milligram quantities o
f each individual member, is reported. An efficient purification; meth
od, using as ''Sequestration Enabling Reagent'' (SER) aminomethylpolys
tyrene resin in the presence of trimethylorthoformate is also describe
d. (C) 1998 Elsevier Science Ltd. All rights reserved.