PRACTICAL METHOD FOR THE COMBINATORIAL SYNTHESIS OF PEPTIDE ALDEHYDES

Authors
HALL BJ SUTHERLAND JD
Citation
Bj. Hall et Jd. Sutherland, PRACTICAL METHOD FOR THE COMBINATORIAL SYNTHESIS OF PEPTIDE ALDEHYDES, Tetrahedron letters, 39(36), 1998, pp. 6593-6596
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
36
Year of publication
1998
Pages
6593 - 6596
Database
ISI
SICI code
0040-4039(1998)39:36<6593:PMFTCS>2.0.ZU;2-V
Abstract
A practical strategy for solid phase synthesis of peptide aldehydes is described. An olefin linker is constructed using Wittig chemistry, af ter peptide synthesis ozonolylic treatment of the linker and subsequen t workup with dimethyl sulphide results in facile isolation of peptide aldehydes. The principle is demonstrated by synthesis of a 3x3x3 arra y of 27 tripeptide aldehydes. (C) 1998 Elsevier Science Ltd. All right s reserved.