Human bites should be considered dangerous injuries with potentially s
erious complications. Their characteristics vary from an uninfected ab
rasion to a serious infection such as cellulitis or osteomyelitis. An
estimated 10% of the injuries become infected; suspected pathogens inc
lude oral and skin flora. Management consists of history and examinati
on, wound care, surgical intervention if necessary, assessment of risk
of disease transmission, and appropriate antibiotic prophylaxis or tr
eatment. The best choice for oral or intravenous antibiotic therapy re
mains the combination of a beta-lactam antibiotic with a beta-lactamas
e inhibitor. Among the most serious human bites are clenched fist inju
ries, which often require surgical intervention and intravenous antibi
otic therapy.