NEFAZODONE - SINGLE VERSUS TWICE-DAILY DOSE

This pilot study involved six men with major depression treated with n efazodone dosed either twice/day or once/day at bedtime. Depression wa s rated before nefazodone therapy and at 4 weeks by the self-report ve rsion of the Hamilton Depression Rating Scale. A simple 10-cm visual a nalog side effect scale for daytime drowsiness was completed at the la tter time. Dosages of nefazodone were at least 400 mg/day The results suggest that nefazodone given once/day at bedtime may be as effective as the currently accepted twice/day regimen, with less daytime drowsin ess.