Surgically removing a focus of epileptogenicity attributable to a mult
iple sclerosis (MS) plaque has not previously been considered a treatm
ent option. Medically intractable partial epilepsy due to a chronicall
y situated MS plaque is uncommon because most cases are self-limiting
or managed with antiepileptic medication. We report a case of partial
epilepsy resulting from such a plaque situated at the gray-white inter
face in the anterior parahippocampal gyrus. A favorable outcome was ac
hieved by resection of the epileptogenic area.