MICROGRAPHIA AFTER THALAMOMESENCEPHALIC INFARCTION - EVIDENCE OF STRIATAL DOPAMINERGIC HYPOFUNCTION

Authors
KIM JS IM JH KWON SU KANG JH LEE MC
Citation
Js. Kim et al., MICROGRAPHIA AFTER THALAMOMESENCEPHALIC INFARCTION - EVIDENCE OF STRIATAL DOPAMINERGIC HYPOFUNCTION, Neurology, 51(2), 1998, pp. 625-627
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
51
Issue
2
Year of publication
1998
Pages
625 - 627
Database
ISI
SICI code
0028-3878(1998)51:2<625:MATI-E>2.0.ZU;2-H
Abstract
A patient with left thalamo-mesencephalic infarction presented with mi crographia in the right hand as the only motor sign. Brain MRI and Tc- 99m ethyl cysteinate dimer (ECD) perfusion SPECT revealed ischemic les ions in the left midbrain and the anterior thalamus, but not in the ba sal ganglia, whereas [I-123]-IPT SPECT demonstrated decreased activity of the [I-123]-IPT in the left striatum. The patient's micrographia m ay be related to a dysfunctional nigrostriatal dopaminergic system sec ondary to ischemic damage to the substantia nigra.