A case of tonic-clonic seizures following chloroquine treatment for le
prosy reactions in a Nigerian male is reported. Seizures were controll
ed with phenytoin sodium capsules. A causal relationship between the s
eizures and chloroquine is suggested. There have been no previous repo
rts of this adverse reaction in leprosy patients receiving chloroquine
for treatment of reactions. The author recommends that chloroquine be
used with caution especially in patients with seizures.