H-1-NMR STUDY ON THE INTERACTION BETWEEN TRANS-CL2PD(DIPEPTIDE)(2) (DIPEPTIDE IS GLYGLYOH AND GLY-L-NVALOH) AND THE DODECANUCLEOTIDE [D(CGCGAATTCGCG)](2)

The metal binding properties of trans-Cl2Pd(glyglyOH)(2) and trans-Cl2 Pd(glynvalOH)(2) towards the oligonucleotide dodecamer [d(CGCGAATTCGCG )](2) duplex, have been studied by 1D and 2D H-1 NMR spectroscopy. A s elective binding of the metal with G(4), followed by G(2) was observed with both complexes. This indicates that an intrastrand GNG(G(2)C(3)G (4))(N-7-N-7) chelation of Pd(II) with the dodecamer duplex may have t aken place. The Pd(II)-duplex interaction is less aggressive with tran s-Cl2Pd(glynvalOH)(2), than with trans-Cl2Pd(glyglyOH)(2). NOE connect ivities in the first case show a through space hydrophobic ligand-liga nd interaction of the dipeptide and oligonucleotide protons. (C) 1998 Elsevier Science Inc. All rights reserved.