FORMULATION AND IN-VITRO CHARACTERIZATION OF NIOSOMES CONTAINING 5-FLUOROURACIL

The present work describes preparation and in vitro, characterization of niosomes containing 5-fluorouracil (5-FU) using non-ionic surfactan t series of sorbitan esters (Spans) by thin film hydration method. Nio somes prepared from Span 40 and Span 60 exhibit higher entrapment of 5 -FU as compared Eo niosomes prepared from Span 80 and Span 85. Cholest erol increases the entrapment of 5-FU into niosomes. Dicetyl phosphate reduces the size of niosomes. The leakage of 5-FU from niosomes reduc es on freeze drying.