MESANGIAL CELL ACTIVATION IN THE COLLAGENOFIBROTIC GLOMERULONEPHROPATHY - CASE-REPORT AND REVIEW OF THE LITERATURE

Authors
NARUSE K ITO H MORIKI T MIYAZAKI E HAYASHI Y NAKAYAMA H KIYOKU H HIROI M KURASHIGE T ENZAN H
Citation
K. Naruse et al., MESANGIAL CELL ACTIVATION IN THE COLLAGENOFIBROTIC GLOMERULONEPHROPATHY - CASE-REPORT AND REVIEW OF THE LITERATURE, Virchows Archiv, 433(2), 1998, pp. 183-188
Citations number
28
Categorie Soggetti
Pathology
Journal title
Virchows Archiv → ACNP
ISSN journal
09456317
Volume
433
Issue
2
Year of publication
1998
Pages
183 - 188
Database
ISI
SICI code
0945-6317(1998)433:2<183:MCAITC>2.0.ZU;2-K
Abstract
Collagenofibrotic glomerulonephropathy is a new disease entity of unkn own pathogenesis, which is characterized by the deposition of type III collagen within the mesangial matrix. We have investigated a case in which many mesangial cells in the type III collagen-deposited glomerul i were alpha-smooth muscle actin (ASMA) positive and showed an increas e of subplasmalemmal filaments, indicating the activation and myofibro blastic transformation. It is suggested that the activated mesangial c ells may synthesize the type III collagen deposited in the subendothel ial space and mesangial matrix.