EFFECTS OF DIOXINS AND FURANS ON LIVER-ENZYMES, LIPID PARAMETERS, ANDTHYROID-HORMONES IN FORMER THERMAL METAL RECYCLING WORKERS

A cross-sectional study was performed to examine the internal exposure of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofuran s (PCDF) in former workers in a nonferrous metal recycling facility. L iver enzymes, lipid parameters, and thyroid hormones were measured to check possible biologic effects. Compared to background levels, the in ternational toxicity equivalent levels of exposed workers were slightl y elevated (median 42 ppt, range 13-281 ppt). The workers also had hig her total PCDF concentrations (median 128 ppt, range 30-1138 ppt). Cor relation analyses demonstrate significant associations with only one l iver enzyme, alanine aminotransferase. There were no such associations with serum cholesterol levels or with serum thyroid hormones. Because of the cross-sectional design of the study, firm conclusions cannot b e drawn. For further evaluation, a follow-up examination appears neces sary.