RADIATION-INDUCED DOUBLE-STRAND MODIFICATION IN CALF THYMUS DNA IN THE PRESENCE OF 1,2-DIHYDROXY-9,10-ANTHRAQUINONE AND ITS CU(II) COMPLEX

Authors
DAS S SAHA A MANDAL PC
Citation
S. Das et al., RADIATION-INDUCED DOUBLE-STRAND MODIFICATION IN CALF THYMUS DNA IN THE PRESENCE OF 1,2-DIHYDROXY-9,10-ANTHRAQUINONE AND ITS CU(II) COMPLEX, Environmental health perspectives, 105, 1997, pp. 1459-1462
Citations number
33
Categorie Soggetti
Public, Environmental & Occupation Heath","Environmental Sciences
Journal title
Environmental health perspectives → ACNP
ISSN journal
00916765
Volume
105
Year of publication
1997
Supplement
6
Pages
1459 - 1462
Database
ISI
SICI code
0091-6765(1997)105:<1459:RDMICT>2.0.ZU;2-Z
Abstract
When cells or DNA is exposed to ionizing radiation, the radicals produ ced in the irradiated sample will modify the base-pair region of the d ouble strands. Effects of 1,2-dihydroxy-9,10-anthraquinone (DHA) and i ts Cu(II) complex on the radiation-induced modification of double-stra nds in calf thymus DNA were studied using ethidium bromide as a fluore scent probe. Our results show that the Cu(II)-DHA complex is more effi cient in modifying the base-pair region in double-stranded DNA compare d to free DHA.