CHOLESTASIS ACUTE HEPATITIS BY AMOXICILLIN-CLAVULANIC ACID - UTILITY OF URSODEOSYCHOLIC ADMINISTRATION IN TOXIC CHOLESTASIS

We report two cases of acute hepatotoxicity after treatment with amoxi cillin-clavulanic. Viral hepatitis serology and autoantibodies were ne gative. Biliary tree obstruction and other etiologies were excluded. A fter discontinuation of the drug the evolution was favorable with clin ical improvement and normalization of liver tests. Liver biopsy made i n one patient showed cholestasis hepatitis with hepatocellular necrosi s and other patient was treated with ursodeoxycholic. Also, we analyse potential utility of ursodeoxycholic acid administration in toxic cho lestasis.