PARA NEOPLASTIC LIMBIC ENCEPHALITIS REVEALING SMALL-CELL ANAPLASTIC LUNG-CANCER - MRI AND IMMUNOLOGY FINDINGS

Paraneoplastic limbic encephalitis (PLE) is a manifestation oi clinico -pathological entity encephalo-myelo-neuropathy associated with anti-n euronal antibodies type I (ANNA-1 also called anti-Hu), isolated PLE i s rare. We reported a case of PLE in a 61-year-old heavy smoker man. A n inappropriate antidiuretic hormone secretion syndrome was associated . Cranial MRI showed hyperintensity in amygdalo-hippocampic regions on T2-weighted sequences which appeared hypointense on TI-weighted seque nces without gadolinium enhancement Anti-Hu antibodies were absent in serum and in CSF. Despite chemotherapy, he died 18 months after diseas e onset. Our patient presented PLE without myeloneuropathy and without ANNA-1 which suggests a different immunopathology.