BRUGADA-SYNDROME ASSOCIATED WITH AN AUTONOMIC DISORDER

A 44 year old man with Brugada syndrome and ventricular fibrillation h ad an autonomic disorder, shown by spectral analysis of heart rate var iability and I-123-MIBG myocardial scintigraphy. Periodic variation of the ST segments was detected by Holter EGG. Increased high frequency power (0.15-0.40 Hz), an index of parasympathetic nerve activity, was observed lust before ST segment elevation. In addition, local dysfunct ion of sympathetic nerves in the left ventricle was detected by I-123- MIBG myocardial scintigraphy. Unbalanced autonomic nerve function play s an important role in inducing Brugada-type ECG signs.