ISOLATED TESTICULAR RELAPSE AFTER BONE-MARROW TRANSPLANT WITH TOTAL-BODY IRRADIATION AND TESTICULAR BOOST IN ACUTE LYMPHOBLASTIC-LEUKEMIA

A 7-year-old boy with Ph+ ALL received an allogeneic BMT in second rem ission. Conditioning included cyclophosphamide 60 mg/kg for 2 days, TB I 2 Gy twice daily for 3 days (12 Gy) and a single testicular boost of 4 Gy, He remained in hematological remission after BMT but developed isolated testicular relapse at 17 months. He underwent orchiectomy of the affected testis, 24 Gy testicular radiotherapy and systemic chemot herapy, He remains in remission 24 months after the testicular relapse . This is the first report of isolated testicular relapse which receiv ed a testicular irradiation boost included in the conditioning.