NASAL GRANULOMA CAUSED BY SCEDOSPORIUM-APIOSPERMUM IN A DOG

A 10-month-old male American Staffordshire terrier was presented to th e Autonomous University of Barcelona Veterinary Teaching Hospital beca use of a 6-month history of a mucopurulent bilateral nasal discharge. The dog had not responded to antibiotics. A follow-up X ray revealed a mixed pattern of osteolysis and increased radiodensity confined to th e nasal cavity. Histologic sections of the biopsy specimens revealed t he presence of granules containing numerous septate hyphae that were h yaline to pale brown and smooth, one-celled, subspherical-to-elongate conidia that were hyaline to brownish green, and bacteria. Cultures yi elded numerous colonies belonging to Scedosporium apiospermum. Suscept ibility tests were performed on the isolated strain. The isolate was s ensitive to ketoconazole, intermediate to clotrimazole, and resistant to amphotericin B, 5-fluorocytosine, fluconazole, and itraconazole. Th e dog was treated with oral ketoconazole. During the treatment a gener al improvement in the lesions was observed. To our knowledge, S. apios permum has not been implicated previously as an etiologic agent of nas al disease in! dogs. This report provides its first description as suc h.