NEUROHYPOPHYSEAL HORMONE AND MELATONIN SECRETION OVER THE NATURAL ANDSUPPRESSED MENSTRUAL-CYCLE IN PREMENOPAUSAL WOMEN

Citation
I. Kostoglouathanassiou et al., NEUROHYPOPHYSEAL HORMONE AND MELATONIN SECRETION OVER THE NATURAL ANDSUPPRESSED MENSTRUAL-CYCLE IN PREMENOPAUSAL WOMEN, Clinical endocrinology, 49(2), 1998, pp. 209-216
Citations number
40
Categorie Soggetti
Endocrynology & Metabolism
Journal title
ISSN journal
03000664
Volume
49
Issue
2
Year of publication
1998
Pages
209 - 216
Database
ISI
SICI code
0300-0664(1998)49:2<209:NHAMSO>2.0.ZU;2-G
Abstract
OBJECTIVE Vasopressin, oxytocin and melatonin have been reported to be influenced by ovarian steroids. The neurohypophysial hormones have al so been shown to display a diurnal pattern of secretion in men, We the refore studied the diurnal pattern of neurohypophysial hormone and mel atonin secretion in premenopausal women and in women on oral contracep tives. DESIGN Healthy normally cycling premenopausal women were studie d over 24 hours during the midfollicular and midluteal phases of the m enstrual cycle. Healthy premenopausal women on oral contraceptives wer e studied over 24 hours at similar times. SUBJECTS Eight healthy norma lly cycling women and 7 healthy premenopausal women on oral contracept ives. MEASUREMENTS Plasma vasopressin, oxytocin and melatonin were mea sured by radioimmunoassay. RESULTS Vasopressin concentrations and its nocturnal peak were highest in the follicular phase of the natural men strual cycle and attenuated in the women on oral contraceptives, Oxyto cin concentrations did not vary between the two phases of the menstrua l cycle, but increased on oestrogen administration. Overall melatonin secretion was augmented in the women on oral contraceptives. CONCLUSIO NS Vasopressin release and its nocturnal peak were greatest in the fol licular phase of the menstrual cycle, while melatonin secretion was au gmented in the women on oral contraception.