SYNTHESIS AND PHYSICOCHEMICAL STUDY OF COLLAGEN HYDROPHOBIC DERIVATIVES

Lauryl, hexyl, and succinoyl derivatives of collagen have been synthes ized using lauryl/hexyl aldehydes and succinic anhydride as reactants. After chemical characterization, the physicochemical properties of th ese three collagen derivatives as well as those of the native protein have been studied. The techniques used were ANS and CF fluorescence, s urface activity, and surface interaction with monomolecular layers of phospholipids. Hydrophobicity values of these preparations do not foll ow the expected order according to their substituents. Lauryl collagen shows a break point in its surface activity, indicative of the presen ce of aggregation.