Pa. Akah et al., EVALUATION OF NIGERIAN TRADITIONAL MEDICINES - II - EFFECTS OF SOME NIGERIAN FOLK REMEDIES ON PEPTIC-ULCER, Journal of ethnopharmacology, 62(2), 1998, pp. 123-127
Antiulcer activity of four medicinal plants, Diodia sarmentosa (whole
plant), Cassia nigricans (leaves), Ficus exasperata (leaves) and Syncl
isia scabrida (leaves), which are commonly used by the Nigerian tradit
ional healers for the treatment of peptic ulcer were investigated. Acu
te toxicity tests were also carried out. The results revealed that the
four extracts possess significant anti-ulcerogenic properties in a do
se-dependent way. They protected rats from aspirin-induced ulcerogenes
is, delayed intestinal transit, increased the pH, and decreased both t
he Volume and acidity of gastric secretion. These results correlate wi
th local use of the plants. (C) 1998 Elsevier Science ireland Ltd. All
rights reserved.