RENAL EFFECTS OF CARBON-DIOXIDE INSUFFLATION IN RABBIT PNEUMORETROPERITONEUM MODEL

To determine the effects of carbon dioxide insufflation on renal funct ion in a pneumoretroperitoneum model, 24 adult New Zealand rabbits wer e divided into four groups, six rabbits in each, The first group under went a 2-hour CO2 insufflation at a pressure of 10 mm Hg in the retrop eritoneal space after balloon dissection. In another group, the same p rocedure was maintained for 4 hours. In the sham-treated groups, the p rocedure was similarly carried out but without CO2 insufflation, In al l our groups, serum and urine creatinine concentrations and renal arte ry and renal vein blood flow rates were determined separately at the b eginning and at the end of the procedure and at 24 hours. Urine output was also recorded at the end of the procedure and at 24 hours, The se rum creatinine in the 2- and 4-hour study groups had increased signifi cantly at the end of the procedure, accompanied by a significant decre ase in the urine creatinine value. Renal artery and renal vein blood f low rates and urine output were reduced in both groups during the stud y. All changes in the serum and urine creatinine, renal artery and vei n flow rates, and urine output was more pronounced in the 4-hour group . All measures returned to their prestudy values by 24 hours. Pneumore troperitoneum causes reversible renal dysfunction, which becomes more pronounced with prolonged insufflation, Further research is needed to show the impact of our findings in high-risk patients undergoing retro peritoneoscopic surgery.