B. Lohff et al., NATURAL DEFENSES AND AUTOPROTECTION - NATUROTHERAPY, AN OLD CONCEPT OF HEALING IN A NEW PERSPECTIVE, Medical hypotheses, 51(2), 1998, pp. 147-151
Recent molecular-biological and molecular-genetic research has shown t
hat important cellular-based autoprotective mechanisms are mediated by
heat-shock proteins (HSPs) or stress-response proteins, also called '
chaperones'. This can happen because cells react to extracellular stim
uli by activating signal transduction pathways which result in activat
ing the genetic program. Molecular biologists and cardiologists are te
mpted to evaluate these phenomena in respect to their potential meanin
g for a better understanding of the complex notions of health and dise
ase. When molecular geneticists or cardiologists talk about autoprotec
tive or natural defense mechanisms, and physicians talk about salutoge
nesis, they all mean something very specific. The phenomenon seen here
belongs to the body's own defense mechanisms which make it capable of
reacting to harmful influences and allow it to stabilize a structure
and/or function of the body for a certain period. Here we see a connec
ting link to the historically grounded term self-healing forces, which
has challenged medical doctors in the different historical periods of
medical science. They tried to explain these effects based on the cur
rent model of the organism. Their understanding of this phenomenon pla
yed a role in defining the concept of health and disease. Thus, it see
ms very fitting to look back into history, since the phenomena discuss
ed here as well as the insights into autoprotective mechanisms will co
ntinue to influence medical understanding of health and disease.