Changes incorporated into the latest edition of the Diagnostic and Sta
tistical Manual of Mental Disorders (DSM-IV; American Psychiatric Asso
ciation, 1994) include a number of features designed to enhance its cr
oss-cultural applicability. However, the overt move toward a culture-s
ensitive nosology is undermined by an implicit assumption of the unive
rsality of its primary syndromes. In this review we argue that the DSM
-IV's underlying thesis of universality based on Western-delineated me
ntal disorders is problematic and has limited cross-cultural applicabi
lity. Research on the cross-cultural manifestation of schizophrenia an
d depression. shows that presentation of these disorders varies signif
icantly across cultures. We conclude by discussing the research and cl
inical implications of these findings. (C) 1998 Elsevier Science Ltd.