Sd. Litvinov, BIOLOGICAL AND CLINICAL-STUDY KINETICS OF BIODEGRADING APATITE-COLLAGEN IMPLANT FOR SUBSTITUTING BONE TISSUE DEFECTS, European journal of drug metabolism and pharmacokinetics, 23(2), 1998, pp. 346-349
We studied kinetics of biotransformation synthetic implant for substit
uting defects of the bone tissue using methods of computer tomography,
scintigraphy and morphology in vivo and in vitro. We found that the c
haracter of biotransformation is dependent on the degree of loaded or
unloaded bone tissue.