The outputs of R&D, such as new research findings and new products and
services, are generated with the aid of specialized problem-solving p
rocesses. These processes are somewhat arcane and have been largely ig
nored in studies of technical change. However, their improvement can s
ignificantly affect the kinds of research problems that can be address
ed, the efficiency and speed with which R&D can be performed, and the
competitive positions of firms employing them. In this paper, we first
describe the general nature of the trial-and-error problem-solving pr
ocesses and strategies for experimentation used in the development of
new products and services. We next discuss the rapid advances being ma
de in problem-solving methods, and the impact such advances can have o
n the competitive position of adopting firms. Finally, we offer a deta
iled case study of the impact one novel experimental method, combinato
rial chemistry, is having on the economics of the drug discovery proce
ss. (C) 1998 Elsevier Science B.V. All rights reserved.