DEVELOPMENT OF A POLYMER-BOUND WITTIG REACTION AND USE IN MULTISTEP ORGANIC-SYNTHESIS FOR THE OVERALL CONVERSION OF ALCOHOLS TO BETA-HYDROXYAMINES

Authors
BOLLI MH LEY SV
Citation
Mh. Bolli et Sv. Ley, DEVELOPMENT OF A POLYMER-BOUND WITTIG REACTION AND USE IN MULTISTEP ORGANIC-SYNTHESIS FOR THE OVERALL CONVERSION OF ALCOHOLS TO BETA-HYDROXYAMINES, Journal of the Chemical Society. Perkin transactions. I (Print), (15), 1998, pp. 2243-2246
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I (Print) → ACNP
ISSN journal
0300922X
Issue
15
Year of publication
1998
Pages
2243 - 2246
Database
ISI
SICI code
0300-922X(1998):15<2243:DOAPWR>2.0.ZU;2-A
Abstract
An efficient combinatorial access to beta-hydroxyamines suitable for a utomation is achieved by the mild oxidation of alcohols to aldehydes b y polymer supported perruthenate (PSP), the subsequent clean olefinati on of the obtained aldehydes by polymer supported Wittig reagents foll owed by the epoxidation of the olefins by dimethyldioxirane (DMDO), an d the final aminolysis of the epoxides with various amines is describe d.