Vs. Berseneva et al., SYNTHESIS OF NOVEL THIAZOLIDIN-4-ONES BY REACTION OF MALONTHIOAMIDE DERIVATIVES WITH DIMETHYL ACETYLENEDICARBOXYLATE, Journal of the Chemical Society. Perkin transactions. I (Print), (14), 1998, pp. 2133-2136
Novel 2,5-dimethylenethiazolidin-4-one derivatives have been prepared
by reaction of malonthioamide derivatives with dimethyl acetylenedicar
boxylate. These compounds exist as separate (E,Z)- and (Z,Z)isomers or
as a mixture. The (E,Z)-isomer is formed as the initial product which
transforms to the (Z,Z)isomer under mild conditions. The structures o
f the obtained compounds have been confirmed by IR and NMR spectroscop
y.