ARTEMISININ MEDIATED ALTERATION OF HEMIN TO A DELTA-MESO OXIDATION-PRODUCT - RELEVANCE TO MECHANISM OF ACTION

Authors
BHAREL S VISHWAKARMA RA JAIN SK
Citation
S. Bharel et al., ARTEMISININ MEDIATED ALTERATION OF HEMIN TO A DELTA-MESO OXIDATION-PRODUCT - RELEVANCE TO MECHANISM OF ACTION, Journal of the Chemical Society. Perkin transactions. I (Print), (14), 1998, pp. 2163-2166
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I (Print) → ACNP
ISSN journal
0300922X
Issue
14
Year of publication
1998
Pages
2163 - 2166
Database
ISI
SICI code
0300-922X(1998):14<2163:AMAOHT>2.0.ZU;2-T
Abstract
Antimalarial drug artemisinin and haemin react in vitro, to give a del ta-mese hydroxy porphyrin isolated as a stable dimethyl esterified zin c complex and characterised as (20-hydroxyprotoporphyrinato dimethyl e ster)zinc(II) by NOESY, visible absorption and ESI-MS; the structure s heds light on the mechanism of action of endoperoxide antimalarials.