DELETION 1P IN A LOW-GRADE CHONDROSARCOMA IN A PATIENT WITH OLLIER-DISEASE

Ollier disease is an uncommon, nonhereditary developmental disorder af fecting enchondral ossification. Cytogenetic analysis of low-grade cho ndrosarcoma in a patient with Ollier disease (multiple enchondromatosi s) revealed an interstitial deletion, del(1)(p11p31.2), as the only ch romosome abnormality. This is the first cytogenetic study of a chondro sarcoma in a patient with Ollier disease. Such patients are at risk of developing chondrosarcoma and, because del(1p) is frequent in chondro sarcoma, it is suggested that this cytogenetic finding is associated w ith early chondrosarcomatous transformation. (C) Elsevier Science Inc. , 1998