CYTOGENETIC ABNORMALITIES IN PRIMARY BRONCHOPULMONARY LEIOMYOSARCOMA OF CHILDHOOD

Primary bronchopulmonary leiomyosarcoma (PBLMS) is a rare malignant ne oplasm in all age groups and only 10 pediatric cases of PBLMS have bee n reported. This report presents cytogenetic findings of a PBLMS from an 8-year-old boy. Tumor diagnosis was established by using routine hi stopathology, immunohistochemistry, and electron microscopy. The karyo type was highly complex, demonstrating consistent structural abnormali ties of chromosomes 1, 5, 6, and 7, relative gain of chromosomes 2 and 11, and relative loss of chromosomes 9, 19, 20, and 22, along with th e presence of multiple marker chromosomes. Cytogenetic results of prev iously reported leiomyosarcomas are reviewed and compared with the pre sent case. (C) Elsevier Science Inc., 1998