TRANSLOCATION (10-12)(Q24-Q15) IN A T-CELL LYMPHOBLASTIC LYMPHOMA WITH MYELOID HYPERPLASIA

We present a case of childhood T-cell lymphoblastic lymphoma (T-LBL) w ith a translocation (10;12)(q24;q15) as a main clonal abnormality, whi ch to our knowledge is the first reported karyotype of this malignancy . The patient's peripheral blood and bone marrow show ed marked leukoc ytosis, mostly myeloid lineage cells, at diagnosis. The enlarged lymph node consisted of two different cell populations: CD2(+)/CD7(+) proth ymic lymphoblasts and a cluster of peroxidase-positive myeloid cells a round vessels. This case might represent a rare but distinct clinical entity of LBL. (C) Elsevier Science Inc., 1998