REACTION BETWEEN ALKYL ISOCYANIDES AND DIMETHYL ACETYLENEDICARBOXYLATE IN PRESENCE OF N,N'-DIMETHYLBARBITURIC ACID - A CONVENIENT ROUTE TO HIGHLY FUNCTIONALIZED 4H-PYRANO[3,2-D]PYRIMIDINE DERIVATIVES

The highly reactive 1:1 intermediate produced in the reaction between alkyl isocyanides and dimethyl acetylenedicarboxylate is trapped by N, N'-dimethylbarbituric acid to yield 4H-pyrano[3,2-d]pyrimidine derivat ives in fairly high yields.