INCREASED CHROMOSOME-ABNORMALITIES IN HUMAN PREIMPLANTATION EMBRYOS AFTER IN-VITRO FERTILIZATION IN PATIENTS WITH RECURRENT MISCARRIAGE

Recurrent miscarriage is a pathological condition induced by maternal and embryonic causes. This paper describes a prospective study to dete rmine the real incidence of aneuploidy for autosomes 13, 16, 18, 21, 2 2, and gonosomes in preimplantation human embryos obtained from patien ts with recurrent pregnancy loss after ovarian stimulation in an IVF-E T programme, Our results indicate that aneuploidy for the chromosomes analysed are abnormally higher in embryos obtained after IVF from recu rrent abortion patients (58%) compared to non-recurrent abortion patie nts undergoing IVE Furthermore, monosomies are six times more frequent than trisomies (47:8) in preimplantation embryos from recurrent abort ion patients. Based on the present study, preimplantation genetic diag nosis (PGD) of embryos obtained from patients with recurrent miscarria ge could prove advantageous in diagnosing abnormal embryos and selecti ng normal embryos for transfer.