PYRIDINES AND PYRAZOLINES FROM SALICYLIC-ACID DERIVATIVES WITH PROPENONE RESIDUE AND THEIR ANTIMICROBIAL PROPERTIES

Reaction of the propenones 1c, d with chlorosulfonyl isocyanate follow ed by hydrolysis gave the corresponding carbamoyloxybenzoates 2a, b. W hile their reaction with ethyl isocyanate afforded the 1,3-benzoxazine -2,4-diones 3a, b. Reaction of 1a, b with aryl hydrazines gave the pyr azolines 4a, d, whereas, with hydrazine hydrate in acetic acid, the ac etyl derivatives 4e, f were produced. 1c, d reacted with malononitrile and ethyl cyanoacetate affording the cyanopyridines 5 and cyanopyrido nes 6 respectively. The products show antimicrobial activities.