Myelofibrosis is not frequent in systemic lupus erythematosus (SLE). A
review in the literature reveals that the co-incidence is rather rare
since there are only a few papers reporting this combination. The fem
ale patient described hereby, presented with thrombocytopenia; followi
ng investigation, the diagnosis of SLE was established and bone marrow
examination revealed an increase of marrow reticulin. Treatment with
steroids reversed both thrombocytopenia and bone marrow fibrosis.