IDENTIFICATION AND SYNTHESIS OF AN OXIDATION-PRODUCT OF TILMICOSIN

Authors
WILLARD KE KIRST HA LEEDS JP READNOUR RS KLINK PR CLEVELAND CM KIEHL DE
Citation
Ke. Willard et al., IDENTIFICATION AND SYNTHESIS OF AN OXIDATION-PRODUCT OF TILMICOSIN, Journal of agricultural and food chemistry, 46(8), 1998, pp. 3265-3271
Citations number
16
Categorie Soggetti
Food Science & Tenology",Agriculture,"Chemistry Applied
Journal title
Journal of agricultural and food chemistry → ACNP
ISSN journal
00218561
Volume
46
Issue
8
Year of publication
1998
Pages
3265 - 3271
Database
ISI
SICI code
0021-8561(1998)46:8<3265:IASOAO>2.0.ZU;2-0
Abstract
During formulation development of the veterinary macrolide antibiotic tilmicosin, an oxidation product of the parent molecule was identified . Use of liquid chromatography/mass spectrometry and nuclear magnetic resonance spectroscopy characterized the structure as 12,13-epoxytilmi cosin, resulting from the oxidation of the double bond at the 12,13-po sition of the macrolide dienone. The synthesis of this oxidation produ ct for confirmation of structural identity is described. The synthetic compound was identical to the isolated oxidation product, 12,13-epoxy tilmicosin.