POSTTREATMENT WITH LOW-MOLECULAR-WEIGHT HEPARIN REDUCES BRAIN EDEMA AND INFARCT VOLUME IN RATS SUBJECTED TO THROMBOTIC MIDDLE CEREBRAL-ARTERY OCCLUSION

Authors
LI PA HE QP SIDDIQUI MM SHUAIB A
Citation
Pa. Li et al., POSTTREATMENT WITH LOW-MOLECULAR-WEIGHT HEPARIN REDUCES BRAIN EDEMA AND INFARCT VOLUME IN RATS SUBJECTED TO THROMBOTIC MIDDLE CEREBRAL-ARTERY OCCLUSION, Brain research, 801(1-2), 1998, pp. 220-223
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
801
Issue
1-2
Year of publication
1998
Pages
220 - 223
Database
ISI
SICI code
0006-8993(1998)801:1-2<220:PWLHRB>2.0.ZU;2-O
Abstract
Low molecular weight heparin (LMWH) has similar efficacy to unfraction ated heparin with less hemorrhagic complications. We studied the neuro protective effect of LMWH on a rat model of focal-ischemia. Our result s revealed that treatment with LMWH at 1 and 3 h following thrombotic MCA occlusion reduced brain edema and infarct size and improved clinic al outcome. Treatment with LMWH initiated at 6 h after thrombin inject ion only partially ameliorated brain damage. (C) 1998 Published by Els evier Science B.V. All rights reserved.