MUTAGENIC ACTIVITY OF 3 SYNTHETIC ISOMERS OF THE FOOD CARCINOGEN 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE (IQ) IN THE AMES TEST

Authors
VIKSE R KLUNGSOYR L GRIVAS S
Citation
R. Vikse et al., MUTAGENIC ACTIVITY OF 3 SYNTHETIC ISOMERS OF THE FOOD CARCINOGEN 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE (IQ) IN THE AMES TEST, MUTATION RESEARCH, 319(4), 1993, pp. 273-278
Citations number
26
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
MUTATION RESEARCH → ACNP
ISSN journal
00275107
Volume
319
Issue
4
Year of publication
1993
Pages
273 - 278
Database
ISI
SICI code
0027-5107(1993)319:4<273:MAO3SI>2.0.ZU;2-U
Abstract
The mutagenic activities of three isomers of IQ, with the pyridine N-a tom at different positions, were measured in the Ames test with Salmon ella typhimurium TA98 and enzymatic activation (S9). All test compound s showed lower activities than IQ. Interestingly, the amount of protei n in the S9 mix does not seem to influence the mutagenic activity of t he '8-IQ' isomer.