A GENERAL PROCEDURE FOR SYNTHESIS OF N-G-ALKYL, AND N-G-ARYL-L-ARGININES AS POTENTIAL NITRIC-OXIDE SYNTHASE INHIBITORS

A general procedure for the synthesis of N-G-alkyl, and N-G-aryl-L-arg inines with relatively high overall yield is reported. The key step in volved the coupling of protected L-ornithine 4 with isothiourea 7 to g ive the fully protected N-G-aryl-L-arginine derivative 8. Subsequent d eprotection of 8 in acidic condition provided the final target compoun d 9 with an overall yield of more than 80%.